Research Focus Areas

• 01

  Osteoporosis Management

  Research on postmenopausal osteoporosis pathophysiology driven by estrogen deficiency accelerating bone resorption, male osteoporosis recognition requiring testosterone assessment and secondary cause evaluation, glucocorticoid-induced osteoporosis prevention through bisphosphonate prophylaxis, bone mineral density measurement via DXA scanning for diagnosis and monitoring, fracture risk assessment using FRAX algorithm incorporating clinical risk factors, and pharmacological interventions including bisphosphonates inhibiting osteoclast activity denosumab blocking RANKL signaling and teriparatide stimulating bone formation.

• 02

  Calcium and Vitamin D Metabolism

  Investigations of calcium homeostasis regulated through intestinal absorption bone resorption and renal reabsorption, vitamin D synthesis from skin 7-dehydrocholesterol photoisomerization and hydroxylation in liver and kidney producing active 1,25-dihydroxyvitamin D, parathyroid hormone secretion responding to serum calcium levels and actions increasing bone resorption and renal calcium retention, fibroblast growth factor 23 regulation of phosphate homeostasis and vitamin D metabolism, and nutritional deficiency states including rickets in children and osteomalacia in adults requiring vitamin D and calcium supplementation.

• 03

  Bone Biomechanics

  Studies examining bone material properties including mineralization degree collagen crosslinking and crystal size influencing tissue-level strength, microarchitectural assessment via high-resolution peripheral quantitative CT measuring trabecular number thickness separation and cortical porosity, finite element modeling predicting fracture risk from bone geometry and material properties, mechanical loading effects on bone formation through mechanosensory osteocytes detecting strain and regulating osteoblast and osteoclast activity, and biomechanical testing of novel implant materials and fracture fixation devices improving orthopedic surgical outcomes.

• 04

  Skeletal Development

  Research on embryonic limb patterning controlled by morphogen gradients and transcription factor networks, endochondral ossification processes including chondrocyte proliferation and hypertrophy followed by vascular invasion and osteoblast differentiation, growth plate regulation determining longitudinal bone growth through growth hormone and insulin-like growth factor signaling, peak bone mass attainment during adolescence influenced by genetics nutrition and physical activity, and genetic skeletal disorders including osteogenesis imperfecta causing brittle bones and achondroplasia resulting in disproportionate short stature requiring multidisciplinary management.

• 05

  Metabolic Bone Diseases

  Publications addressing hyperparathyroidism causing hypercalcemia bone loss and kidney stones treated with parathyroidectomy, hypoparathyroidism resulting in hypocalcemia treated with calcium and active vitamin D supplementation, Paget disease characterized by excessive disorganized bone remodeling managed with bisphosphonates, renal osteodystrophy complicating chronic kidney disease requiring phosphate restriction and calcitriol therapy, and tumor-induced osteomalacia caused by FGF23-secreting mesenchymal tumors requiring surgical resection for cure demonstrating diverse pathophysiological mechanisms affecting skeletal health.

• 06

  Fracture Prevention

  Studies on fall prevention interventions including balance training exercise programs environmental modifications and medication review reducing fall-related fractures particularly hip fractures in elderly populations, pharmacological fracture prevention through antiresorptive agents reducing vertebral and non-vertebral fractures, anabolic therapies stimulating new bone formation achieving greater bone mineral density gains, sequential therapy optimizing long-term fracture protection through combining anabolic followed by antiresorptive treatment, and post-fracture care including secondary fracture prevention programs identifying and treating underlying osteoporosis preventing subsequent fractures improving patient outcomes and quality of life.