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Auricular Vagus Nerve Stimulation Improves Chronic Pain and Pain-Related Cytokine Levels: A Clinical Study

Abstract:

Periauricular Vagus Nerve Stimulation (pVNS) has been proven safe and effective in reducing chronic pain and related comorbidities in numerous clinical studies. This multicenter, interventional study used a non-randomized, interrupted time-series analysis to test the efficacy of an 8-week treatment protocol using the Stivax neurostimulator device. Subjects (n=33, 15 F, 18 M, age 40-77) were recruited at 3 clinic sites in California and Colorado. All subjects had long-term chronic pain and had failed other treatments. Subjects were treated with the Stivax device 3 times (2 weeks on, 1 week off). Subjective assessments of pain (Visual Analog Scale), disability (Oswestry Disability Index), depression (PHQ-9), and activity (IPAQ-E) were collected at baseline and weekly. Objective blood levels of pain-related cytokines collected at the end of weeks 2 and 8. Most subjects reported reduced pain, disability, and depression, with increased activity levels. At the end of we...

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BIOREMEDIATION TO REDUCE PESTICIDE POLLUTION ON AGRICULTURAL LAND

Abstract:

Environmental pollution until this moment still become crucial environmental problem. Environmental pollution can occur anywhere, one of them is in agriculture sectoral. Environmental pollution in the agriculture area caused by usage of chemical pesticide for managing agriculture. Using chemical pesticide can leave residue that raises pollution. Bioremediation become one of the solutions for the problem. Besides it is environmental friendly, bioremediation is also easy to apply and cheap. This study aim to examine the potency of Bacillus altitudinis , Bacillus subtilis, Pseudomonas b68, and Pseudomonas b70 as biological agent for bioremediation of pesticide residues in soil Biological agent was incubated in liquid medium polluted pesticide type fungicide for 15 days on some variation concentration pesticides (100, 200, 300) mg/L. Concentration of pesticides ...

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Monk Fruit is a Safe, Natural, Non-Caloric Sweetener in Individuals with Type 2 Diabetes

Abstract:

Non-nutritive sweeteners are used as adjuncts in treating patients with diabetes to reduce carbohydrate intake. Monk fruit is an FDA-approved1 natural NNS2-. There is no information regarding the use of monk fruit in individuals with T2DM3. The primary objective was to compare the glycemic response to sucrose and monk fruit in individuals with and without T2DM. Twenty-six individuals with T2DM and 29 without DM4 underwent two oral glucose tolerance tests5 after a 250-ml sucrose- or monk fruit-sweetened beverage. Glucose levels were measured at 0, 30, 60, 90, and 120 minutes. An appetite scale was used before and after the procedure. Insulin levels were measured in ten randomly selected individuals from the control group. The glucose levels at 30 and 120 min were significantly lower in both groups in the monk fruit-OGTT. There was a peak response in the T2DM group at 90 min (median, IQR, 247 mg/dL, 203-293) wit...

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Pyrexia And Liver Injury After A Second SARS-CoV-2 Vaccination: Macrophage Activation Manifested In Liver

Abstract:

Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-Co V-2) has contributed to control of the coronavirus disease 2019 (COVID-19). On the other side, vaccination of SARS-CoV-2 could trigger autoimmune or inflammatory diseases. We present a 50-year-old female with well-controlled optic neuromyelitis with prednisolone (PSL) maintained at a dose of 2.5 mg/day. She ran a fever and liver injury was indicated 5 weeks after a second COVID-19 vaccination (BNT162b2 mRNA/Pfizer ). Liver biopsy showed accumulation of macrophages around the central veins, identified using anti-CD68 antibodies. As the treatment, cyclosporine A improved liver injury. COVID- 19 vaccination may have triggered liver inflammation due to cytokine storm via macrophage activation in the liver.

...

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Low Seroprevalence of Brucella Spp. among Remote Colombian Communities from the Sierra Nevada De Santa Marta

Abstract:

Brucella species cause a high burden of disease globally, infecting both humans and animals; however, One Health has been under-appreciated in Colombia. This study aimed to determine the seroprevalence of Brucella spp. in two remote indigenous communities from the Sierra Nevada de Santa Marta, Colombia. These communities live in close contact with their livestock, indicating a potential susceptibility to zoonotic pathogens. The livestock routinely kept by these communities include cattle, small ruminants and pigs, the known hosts of human pathogenic Brucella spp.. A low level of exposure to Brucella spp. was documented, with only one positive participant among 539 participants (0.2%; 95% CI 0.0 – 1.0). Nevertheless, due to the high risk that zoonoses pose, we recommend discussions with the community for th...

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Size structure, weight-length relationship and condition factor K of the endogenous Cameroon giant frog Conraua goliath (Boulenger, 1906) in its natural environment

Abstract:

The growth characteristics of Conraua goliath (Boulenger, 1906), an endemic and endangered species in Cameroon, were evaluated in its natural habitat between October 2021 and November 2022 in order to contribute to its domestication and conservation. For this purpose, 139 specimens (55 males, 55 females, and 29 individuals of undifferentiated sex) were collected by fishermen from 3 sites (Loum, Penja, and Nlonako) in the Department of Moungo, Coastal Region of Cameroon. The frogs were measured, and their growth parameters were determined after dissection and macroscopic and microscopic observations. The maximum size observed is 33.5 cm (SVL) and 2529 g body weight (BW), and the minimum size is 5.3 cm (SVL) and 12 g body weight (BW). This species is more abundant in the rainy season, in frogs between 18 and 24 cm, and has a Caucasian and uni-modal size structure. Independent of sex and season, this species has a significant and high regression coef...

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Improving Effective Screening and Management of Obesity in an Urgent Care Clinic

Abstract:

Background

Nearly 40% of the adult population in the United States are considered obese by current standards, which equates to approximately 93 million people. Obesity is a chronic disease that is linked to more than 40 other diseases, including hypertension, heart disease, stroke, diabetes, and at least 13 distinct types of cancers. The direct and indirect costs of obesity have been estimated at up to $210 billion annually.

Local Problem

In Cumberland County, North Carolina, 34% of the adult population was considered obese. The aim of this quality improvement study was to increase effective care (screening, patient engagement, and referral to treatment) in adult patients with a BMI greater than 30 kg/m2 to 75% within 90 days.

Method...</p> <a class="btn btn-primary blue-btn text-uppercase my-4" href="https://oap-researcharticles.org/obesity-management/article/improving-effective-screening-and-management-of-obesity-in-an-urgent-care-clinic-1982">Read Article</a> </div> </div> <div class="col-md-6 mb-3 aos-item aos-init " data-aos="fade-up"> <!-- child-div --> <div class="article-section p-3"> <h4 class="article-title title-border pb-3"> Correlations with Congenital Syphilis in the United States: A Cross-Sectional Study </h4> <h4 class="article-title fw-700">Abstract:</h4> <p><abstract> <p>Syphilis is caused by the bacterium <italic>Treponema pallidum</italic> and is transmitted from human to human through sexual contact. Congenital syphilis (CS) occurs when the mother transmits the infection to the fetus. Clinical manifestations of CS include anemia, hepatosplenomegaly, blindness, deafness, meningitis, and deformities in bone structure. The number of cases of CS have increased over the past decade in the United States according to the CDC. A study was conducted correlating the number of Medicaid enrollees in 2020, the number of uninsured persons in 2020, and the number of cases of COVID-19 in 2020 to cases of CS in the United States in 2021. A Spearman rank correlation analysis was done using SPSS. Results were statistically significant for all three pairs of variables with positive correlations; Medicaid enrollment and CS cases (r = 0.735, P<.05), uninsured persons with CS cases (r = 0.713, P<.05), COVID-19 cases and CS cases (r = 0.689, P&l...</p> <a class="btn btn-primary blue-btn text-uppercase my-4" href="https://oap-researcharticles.org/international-journal-of-sexually-transmitted-diseases/article/correlations-with-congenital-syphilis-in-the-united-states-a-cross-sectional-study-1983">Read Article</a> </div> </div> <div class="col-md-6 mb-3 aos-item aos-init " data-aos="fade-up"> <!-- child-div --> <div class="article-section p-3"> <h4 class="article-title title-border pb-3"> Soluble Biobased Substances in soil or Salicylic Acid on leaves affect the foliar pH and soil biovariability of Grapes-as explained by the NIR Spectroscopy of Litterbags and Teabags </h4> <h4 class="article-title fw-700">Abstract:</h4> <p><abstract> <p>The purpose of the trial was to check the effects of two grapevine treatments on the plant activity and on the bioactivity and biovariability of the soil. An alkaline complex of Soluble Biobased Substances (SBS) was used in soil at 30 g per plant in a single solution. Salicylic Acid (SA) was used on leaves at 150 mg l<sup>-1 </sup>every two weeks at 50 ml plant. The plants were examined for their foliar pH and NIR spectra. The soil bioactivity was monitored by means of hay-Litterbag-NIRS (LBN) in combination with the Teabag Index (TBI), using rooibos and green tea that had been buried for 60 days. The evolution of the TBI presented here concerns the TBI-NIRS spectroscopic method used for discriminant analysis. A new algorithm was used to estimate the soil microbiome from the green Teabag spectra. The obtained results showed that the plants and the soil responded to the treatments. 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