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Protection Side Chain of Lysine by Host-Affinity Molecules during Solid Phase Peptide Synthesis in Aqueous Phase

Abstract:

A new approach to protecting the side chain of lysine during solid-phase peptide synthesis in an aqueous environment is explored. The objectives of this study are twofold: 1) to reduce the consumption of chemical solvents in peptide synthesis, and 2) to lower the costs associated with lysine side chain protection. In an effort to minimize the usage of organic solvents in amino acid side chain protection for peptide synthesis,18-crown-6 molecule (18C6) was introduced as protective agent for Lysine (Lys) side chain protection. 18C6 is utilized to protect ε-amino group of on side chain of Lys in peptide synthesis. 18C6 features cavity at its center. The 18C6 molecules exhibit a unique and distinctive host-guest affinity towards ε-amino group on side chain of Lys. 18C6 bind to Lys side chain through hydrogen bonds with ε-amino group of Lys, eliminating the need for chemical reactions in organic solvents to attach protective molecules to the side chain groups. This ...

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Predictors of COVID-19 Vaccine Hesitancy in North-Central Nigeria

Abstract:

COVID-19 vaccine hesitancy has emerged as a major challenge to global efforts to control the pandemic, particularly in Nigeria, where hesitancy to other effective vaccines such as polio and measles has been widely reported. Several individual, societal, and structural factors contribute to this behaviour and prevent the effectiveness of COVID-19 prevention efforts.

Objectives

This study sought to identify the predictors of COVID-19 vaccine hesitancy in the seven states of North-Central, Nigeria.

Methods

A population-based cross-sectional online survey was conducted among residents using a semi-structured questionnaire adapted from the WHO SAGE vaccine hesitancy scale and distributed via social media networks over 8-weeks.

...

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Genotypic Diversity among Salmonella Typhi Isolated from Children Living in Informal Settlements in Nairobi, Kenya

Abstract:

The persistence of multidrug-resistant (MDR) Salmonella Typhi (S. Typhi) is a challenge especially in regions where typhoid is endemic. Surveillance of circulating genotypes of MDR S. Typhi is crucial in typhoid acute cases and carriers. This study aimed to investigate genotypic diversity of S. Typhi from symptomatic and asymptomatic children in endemic settings in Nairobi, Kenya. Symptomatic and asymptomatic individuals’ ≤ 16 years were recruited at four health facilities and tested for typhoid through stool cultures. The S. Typhi isolates were subjected to antibiotic susceptibility testing to investigate multidrug resistance. The MDR S. Typhi isolates’ DNA was extracted and illumina sequenced. Raw reads were de novo assembled and analyzed by pathogen-watch. From the 90 seque...

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Prevalence and Antifungal Susceptibility of Candida species from patients attending Rivers State University Teaching Hospital, Nigeria

Abstract:

The development of medical therapy and patients profile has led to a rise in the incidence of nosocomial fungal infection. The frequency of candidiasis has surged worldwide, and the prevalent of healthcare diseases are now Candida species. Candida species causes a range of human infections known as Candidiasis. The non-albicans Candida (NAC) species have recently superseded Candida albicans as significant opportunistic pathogens. The study was conducted to determine the prevalence and antifungal susceptibility of Candida species isolated from various Clinical samples in Rivers State University Teaching Hospital, Port Harcourt, Nigeria. A total of 206 clinical specimens from male and female patients of all ages were sampled in the Department of Microbiology, Rivers State University Teaching Ho...

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Health-Related Quality of Life Perception Among Older Persons with Non-Communicable Diseases in Primary Healthcare Facilities: A Qualitative Inquiry

Abstract:

Background

The understanding of older persons with non-communicable diseases (NCDs) regarding health well-being is paramount and can translate to increased self-efficiency, independence, and enhanced well-being. However, little is known about older persons' understanding of the concept of health-related quality of life (HRQoL) in Uganda. The study explored perceptions and unveiled understanding of older persons with NCDs on HRQoL in central Uganda.

Methods

This exploratory qualitative study design involved 23 participants recruited from selected Primary healthcare facilities in Central Uganda. Thematic analysis using an inductive approach generated themes that informed the study's qualitative findings.

Results</tit...</p> <a class="btn btn-primary blue-btn text-uppercase my-4" href="https://oap-researcharticles.org/international-journal-of-global-health/article/health-related-quality-of-life-perception-among-older-persons-with-non-communicable-diseases-in-primary-healthcare-facilities-a-qualitative-2154">Read Article</a> </div> </div> <div class="col-md-6 mb-3 aos-item aos-init " data-aos="fade-up"> <!-- child-div --> <div class="article-section p-3"> <h4 class="article-title title-border pb-3"> Exercises Pursued by Older Adults with Osteoarthritis and Their Structural Impacts are Hard to Uncover; a Scoping Review of Selected 1970-2024 Studies</h4> <h4 class="article-title fw-700">Abstract:</h4> <p><abstract> <p>Persons with osteoarthritis often have signs of reduced muscle strength. Some studies suggest that this strength could be improved with exercise. However, does this form of therapy improve the disease status as assessed by improvements in cartilage viability, a hallmark of the disease? This brief describes the possible usage of exercises in general, plus those known to improve strength and function, and reduce pain and whether structural impacts that favor or impede disease regression have been observed in this context among the older osteoarthritis adult population. Since exercise may also do harm, rather than good in osteoarthritis management if excessive, contra indicated, or suboptimal, what is the consensus in this regard in 2024? </p> </abstract>...</p> <a class="btn btn-primary blue-btn text-uppercase my-4" href="https://oap-researcharticles.org/aging-research-and-healthcare/article/exercises-pursued-by-older-adults-with-osteoarthritis-and-their-structural-impacts-are-hard-to-uncover-a-scoping-review-of-selected-1970-202-2153">Read Article</a> </div> </div> <div class="col-md-6 mb-3 aos-item aos-init " data-aos="fade-up"> <!-- child-div --> <div class="article-section p-3"> <h4 class="article-title title-border pb-3"> Primary Membranous Nephropathy Flare After COVID-19 Vaccination</h4> <h4 class="article-title fw-700">Abstract:</h4> <p><abstract> <p>Primary membranous nephropathy (MN) is due to autoantibodies to phospholipase A2 receptor (PLA2R Ab). It is unclear whether COVID-19 vaccines can trigger flares of glomerular diseases such as primary MN. There have been increasing reports of glomerular diseases presenting or flaring after receipt of COVID-19 vaccines. We present a patient with primary MN who developed nephrotic syndrome after receiving her second mRNA-1273 COVID-19 vaccine with positive PLA2R Ab. Renal biopsy confirmed primary MN. She was treated for her primary MN flare with rituximab in a manner similar to non-vaccine-associated MN, which led to significant reduction in both PLA2R Ab level and proteinuria. This case adds to the growing literature on MN flares after receipt of mRNA COVID-19 vaccines. Close follow-up of patients with primary MN and other glomerular diseases after COVID-19 vaccination is ...</p> <a class="btn btn-primary blue-btn text-uppercase my-4" href="https://oap-researcharticles.org/nephrology-advances/article/primary-membranous-nephropathy-flare-after-covid-19-vaccination-2165">Read Article</a> </div> </div> <div class="col-md-6 mb-3 aos-item aos-init " data-aos="fade-up"> <!-- child-div --> <div class="article-section p-3"> <h4 class="article-title title-border pb-3"> Ethics of Modern Stem Cell Research and Therapy: Current Critical and Interdisciplinary Perspectives</h4> <h4 class="article-title fw-700">Abstract:</h4> <p><abstract> <p>From an academic and clinical point of view, stem cell therapy represents one of the most promising advances in modern medicine, with the ability to partially induce the regeneration of acutely injured or chronically damaged tissues. Stem cell research provides new opportunities for the treatment of various conditions, among them diabetes mellitus, HIV, cardiovascular diseases, and neurodegenerative illnesses. Stem cell therapy is currently not FDA-approved in the US (except for certain blood cancers). While bioethics and religion have mostly discussed the source of cells, i.e., embryonic cells that require the destruction of embryos versus adult tissue for research purposes, we also discuss the controversies with regard to currently offered therapies, and marketing of unapproved procedures from a scientific, clinical, and religious viewpoint. </p> </abstract>...</p> <a class="btn btn-primary blue-btn text-uppercase my-4" href="https://oap-researcharticles.org/aging-research-and-healthcare/article/ethics-of-modern-stem-cell-research-and-therapy-current-critical-and-interdisciplinary-perspectives-2166">Read Article</a> </div> </div> <div class="col-md-6 mb-3 aos-item aos-init " data-aos="fade-up"> <!-- child-div --> <div class="article-section p-3"> <h4 class="article-title title-border pb-3"> Splenectomy Reports</h4> <h4 class="article-title fw-700">Abstract:</h4> <p><abstract> <sec id="idm1842274780"> <title>Introduction

It was seen that splenectomy creates a disability situation in an individual, and in order to eliminate it, people applied to health boards to get a report to eliminate their social and economic losses recognized to them.

 Objective

To examine the reason for surgery, method of surgery and the type of report they wanted to receive in splenectomised patients who applied to the general surgery committee polyclinic in 2017-2018-2019-2020 and 2023 when the pandemic ended.

 Materials and Methods

Patients who applied to general surgery outpatient clinics were asked whether they had any surgery related to general surgery, and epicrises and pathology results of splenectomised patients were seen and recorded.

...

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Ultrasound Guided Pericardial Effusion Training Model for Neonates

Abstract:

This methods article presents a neonatal pericardial effusion training model using ultrasound. It details materials, construction, and training objectives to support procedural competence.

...

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