Aims and Scope
Journal of Thyroid Cancer advances thyroid cancer diagnosis, treatment, and survivorship through mechanistic, translational, and clinical research.
JTC curates research across mechanistic, translational, and clinical domains of thyroid cancer. Our scope encompasses molecular studies, diagnostic innovations, surgical outcomes, systemic therapies, and survivorship care that improve patient outcomes.
Molecular Genetics and Oncogenesis
Genetic mutations driving thyroid malignancy initiation and progression.
- BRAF, RAS, RET/PTC rearrangements
- Epigenetic modifications
- Chromosomal instability
- Hereditary syndromes (MEN2, Cowden)
Signaling Pathway Dysregulation
Mechanistic analysis of aberrant pathway activation in carcinogenesis.
- MAPK/ERK cascade
- PI3K/AKT/mTOR axis
- Wnt/beta-catenin signaling
- Receptor tyrosine kinases
Tumor Microenvironment
Stromal interactions influencing tumor progression and immune evasion.
- Immune cell infiltration
- Fibroblast activation
- Extracellular matrix remodeling
- Paracrine signaling networks
Biomarker Discovery
Molecular markers with mechanistic rationale for clinical translation.
- Disease detection markers
- Subtype classification
- Prognostic stratification
- Recurrence prediction
Cellular Metabolism
Metabolic reprogramming supporting cancer cell survival and proliferation.
- Altered glucose uptake
- Lipid metabolism changes
- Mitochondrial function
- Bioenergetic adaptations
Epithelial-Mesenchymal Transition
Molecular mechanisms enabling invasion and metastatic potential.
- EMT transcription factors
- Phenotypic plasticity
- Invasion pathways
- Metastatic colonization
Scope Alignment: JTC welcomes mechanistic studies exploring molecular pathways, translational research linking molecular findings to clinical decisions, and clinical investigations improving thyroid cancer diagnosis, treatment, and survivorship outcomes.
Original Research
Mechanistic studies with validated experimental approaches (5,000-7,000 words)
Reviews
Comprehensive syntheses of molecular pathways (6,000-8,000 words)
Methods
Novel techniques for studying thyroid cancer biology (3,000-4,000 words)
Short Communications
Rapid reports of significant mechanistic findings (2,000-3,000 words)
JTC maintains rigorous standards for mechanistic research:
- Clear hypothesis with molecular or cellular focus
- Validated experimental models appropriate to the research question
- Reproducible methodology with appropriate controls
- Statistical rigor and transparent data presentation
- Mechanistic interpretation supported by evidence
- Data availability for key findings
Angiogenesis
VEGF signaling, endothelial recruitment, and vascular network formation supporting tumor growth.
Cell Cycle Dysregulation
Checkpoint aberrations, cyclin/CDK imbalances, and p53 pathway disruption in thyroid malignancies.
Experimental Models
Cell lines, patient-derived xenografts, organoids, and CRISPR-engineered systems.
Submit Your Research
Share your thyroid cancer research with a global clinical and scientific audience.
