Hajare Rahul, Profile of Similarity of Electron Withdrawing Structure Towards Analgesic-Anti-Inflammatory Activity of The Novel Isatin Analogue: Design and Implementation of Phase I Drug Discovery, International Physiology Journal, Volume 1, Issue 2, 2018, Pages 7-14, ISSN 2578-8590, https://doi.org/10.14302/issn.2578-8590.ipj-18-2113.
(https://oap-researcharticles.org/ipj/article/748)
Abstract: Isatin (1H-indole-2,3-dione ) and derivatives demonstrate a diverse array of biological activities. Isatin and 5-halo derivatives has reacted to form the schiff’s bases , mannich bases and friedal craft alkylation’s to form C-C, C-N, C=N bonds. From the spectral studies, isatin has undergoes reaction at C-3 and N-1 position and synthesized lead in present schme and seen the similarity of structure and analgesic-anti-inflammatory activity.
Keywords: Schiff’s base; n-benzylation; dimethylformamide; anti-inflammatory; analgesic.