Sarmistha Mitra, Md. Kamrul Hossain, MicroRNA: New Era for Therapeutic Strategy in Ischaemic Heart Disease, Journal of Hypertension and Cardiology, Volume 2, Issue 3, 2017, Pages 20-31, ISSN 2329-9487, https://doi.org/10.14302/issn.2329-9487.jhc-17-1536.
(https://oap-researcharticles.org/jhc/article/506)
Abstract: Over the last few decades, many research works highlighted the role of miRNAs on cardiac diseases. Ischaemic heart disease (IHD) or coronary heart disease is a condition that is mainly caused by atherosclerosis. It has been established that microribonucleic acids regulate many factors that are involved in the development and pathophysiology of IHD. As a result, there are great potential opportunities for miRNAs to be used as a biomarker for disease differentiation, as well as novel drug targets or therapeutics for the treatment and also as a diagnostic approach. As it is now evident that miRNAs play critical roles in the disease mechanisms, this review article tried to focus on the pathway, in which; the miRNAs stimulate the IHD to develop. By understanding the mechanisms, it will be possible to present a complete strategy of IHD treatment and also solving all the impediments that are highlighted in this article. Still, there are a number of limitations and obstacles on the way of developing a proper therapeutic approach that can be approved and well accepted. This review is mainly dependent on the potential of miRNAs as a promising arena on the field of cardiac treatment and the possible obstacles that are needed to be explored and overcome.
Keywords: miRNA; Ischaemic Heart Disease; Therapeutics