Soon Hoe BSc (Hon) Ho, Raising HLA-E-Restricted HIV-1-Specific Immune Responses Through T Cell Vaccination: A Hypothesis, International Journal of Clinical Microbiology, Volume 1, Issue 1, 2017, Pages 1-7, ISSN 2690-4721, https://doi.org/10.14302/issn.2690-4721.ijcm-17-1533.
(https://oap-researcharticles.org/ijcm/article/492)
Abstract: This essay draws on recent evidences from SIV vaccination studies in rhesus macaques to argue for the potential importance of HIV-1-specific CD8+ T cells restricted by the non-classical major histocompatibility complex, HLA-E, in controlling HIV-1 replication. It then seeks to present a possible method of inducing such responses through the procedure of T cell vaccination using activated autoimmune CD4+ T lymphocytes ‘infected’ with inactivated replication-incompetent structurally intact HIV-1 particles. It is hoped that the argument presented here will interest many of those involved in HIV/AIDS research and others in the general scientific community.
Keywords: Human immunodeficiency virus-1; T cell vaccination; non-classical major histocompatibility complex; human leukocyte antigen-E; activated CD4+ T cells