Qaiser Shah Syed, Momin Saima, Synthesis of Labeled Rifabutin Dithiocarbamate: A Potential Mycobacterium Tuberculosis Imaging Agent, Journal of Glycomics And Metabolism, Volume 1, Issue 2, 2017, Pages 12-23, ISSN 2572-5424, https://doi.org/10.14302/issn.2572-5424.jgm-16-1352.
(https://oap-researcharticles.org/jgm/article/432)
Abstract: In this investigation, Rifabutin dithiocarbamate (RFND) was labeled with Technetium-99m (99mTc) using tricarbonyl technique. The labeled RFND was further characterized in terms of radiochemical purity, stability in saline & serum, in vitro bacterial binding, biodistribution in animal model rats and for scintigraphic accuracy in animal model rabbit. Finally different radiobiological characteristics of the 99mTc(CO)3-RFND was compared with the recently reported 99mTc-RFN. It was observed that the dithiocarbamate form of RFN showed better radiochemical purity, stability in saline, bacterial binding, biodistribution and targeted imaging than the recently reported 99mTc-RFN. These better radiobiological parameters posed 99mTc(CO)3-RFND as a more reliable agent for tuberculosis imaging.
Keywords: Rifabutin dithiocarbamate; bacterial binding; biodistribution; scintigraphy