Rosas-Peralta Martin, Palomo-Piñón Silvia, Borrayo Sánchez Gabriela, Pérez Rodríguez Gilberto, Ramón Paniagua-Sierra José, Cardiorenal Signaling Pathways in Heart Failure: Good and Bad News, Journal of Hypertension and Cardiology, Volume 1, Issue 4, 2016, Pages 23-39, ISSN 2329-9487, https://doi.org/10.14302/issn.2329-9487.jhc-15-864. (https://oap-researcharticles.org/jhc/article/250) Abstract: This article reviews heart–kidney signaling in heart failure, contrasting adaptive and maladaptive pathways. It discusses neurohormonal activation, fibrosis, and emerging therapeutic targets. Keywords: Heart Failure; Heart-Kidney interactions; Cardiorenal syndrome; diastolic dysfunction; inflammation; fibrosis.