Bhoite Rachana, Shanmugam Shobana, Lalithya Pratti Varalakshmi, Satyavrat Vinita, Rajagopal Gayathri, Mohan Anjana Ranjit, Mohan Viswanathan, Estimation of Glycemic Index of Liver Nutritional Supplement and its Importance in Liver Nutrition, Journal of Human Health Research, Volume 2, Issue 1, 2023, Pages 1-8, ISSN 2576-9383, https://doi.org/10.14302/issn.2576-9383.jhhr-23-4713.
(https://oap-researcharticles.org/jhhr/article/2009)
Abstract: A global increase in incidence of chronic liver disease (CLD) indicated the necessity of dietary and lifestyle modification. Low glycemic index (GI) diet was reported to have a significant role in controlling diabetes caused by liver dysfunction. The International Standards Organisation (ISO) has standardized the determination of GI of a food in healthy individuals. This study aimed to estimate GI value of a high protein, energy dense liver nutritional supplement. This cross-over randomized controlled study randomly allotted 15 participants to consume either reference food 27.5 gm glucose (glucose monohydrate) or 77 gm nutritional supplement (equivalent to 25 gm of available carbohydrates); switching to another arm was done after 3 days wash-out period. After overnight fast, blood samples were collected at 15, 30, 45 and 60 minutes post-consumption of s upplement or reference food. The GI was calculated from the incremental area under the blood glucose response elicited by the nutritional supplement as a percentage of the response after consumption of 27.5 gm of glucose (glucose monohydrate) by the same participant using a standard formula. Mean GI of the nutritional supplementwas estimated as 11.4 ± 2.4.With the consumption of this nutritional supplement, the blood glucose levels were reduced at all postprandial time points, compared to the reference food. The liver nutritional supplement tested has a low GI, and comparatively slower and more sustained blood glucose response. Therefore, it can be used in patients with CLD to prevent CLD-associated metabolic complications and improve health outcomes and quality of life.
Keywords: Blood glucose; Chronic liver disease; Liver nutrition supplement; Low glycemic index foods; Nonalcoholic fatty liver disease.