Wu Jianqing, Zha Ping, A Cancer Theory: The Central Nervous System’s Adaptive Changes Make Chronic Diseases Incurable, Journal of Colon And Rectal Cancer, Volume 1, Issue 3, 2022, Pages 38-62, ISSN 2471-7061, https://doi.org/10.14302/issn.2471-7061.jcrc-22-4139. (https://oap-researcharticles.org/jcrc/article/1806) Abstract: We examined special roles of the Central Nervous System (CNS) in an attempt to resolve the puzzle that chronic diseases cannot be cured in medicine. By exploring a skill-learning model, we found that the CNS is able to remember certain information reflecting biochemical and cellular (B&C) processes in the body. From the skill-using ability, we found that the CNS is able to control basic B&C processes that drive and power the skill. From the ability to adjust forces and moving direction of body parts, we infer that the CNS is able to adjust B&C processes that control physical acts. From this controlling capability, we inferred that the CNS must also store certain information on the baseline B&C processes, is able to up-regulate or down-regulate the B&C processes, and make comparisons in performing its regulatory functions. We found that chronic diseases are the results of deviated baseline B&C processes, the CNS plays a role in maintaining deviated baseline B&C processes, and protects the body state of a fully developed disease. The three CNS roles can explain that cancer progresses with increasing malignancy, cancer quickly returns after a surgery, cancer cells repopulate after chemotherapy and radiotherapy, cancer patients develop drug resistance inevitably, immune cells rebound after suppression, etc. We further showed that long-term exercises generally can correct part of the departures in B&C processes and thus help to reverse chronic diseases. Finally, we propose strategies for resetting the CNS’ state memory as an essential condition for curing chronic diseases and cancer. Keywords: Cancer theory; CNS central nervous system; lost anti tumor immunity; exercise skills; incurable diseases; failure of medicine