Adiche Chiaa, El Abed Douniazad, A One-Pot Synthesis of Sulfonyl Amidinesvia Three-Component Reaction Under Mild and Solvent-Free Conditions, Journal of Current Scientific Research, Volume 1, Issue 3, 2021, Pages 1-12, ISSN 2766-8681, https://doi.org/10.14302/issn.2766-8681.jcsr-21-3805.
(https://oap-researcharticles.org/jcsr/article/1742)
Abstract: A convenient one-pot synthetic protocol for the preparation of sulfonyl amidines has been developed. The procedure combines three-component reaction of sulfonyl azide, methyl propiolate and secondary cyclic amine coupling in one sequence without any solvent or catalyst and at room temperature. The reaction proceeds smoothly and a variety of desired sulfonyl amidines were obtained in moderate to good yields. This protocol has synthetic advantages in terms of low environmental impact and very short reaction time.
Keywords: Multicomponent reactions; sulfonylamidines; terminal alkyne.