Isea Raúl, Quantitative Computational Prediction of the Consensus B-cell Epitopes of 2019-nCoV, Journal of Current Viruses and Treatment Methodologies, Volume 1, Issue 1, 2020, Pages 42-47, ISSN 2691-8862, https://doi.org/10.14302/issn.2691-8862.jvat-20-3278.
(https://oap-researcharticles.org/jvat/article/1319)
Abstract: The goal of this paper is to obtain the numerical consensus of B cell epitopes from the three-dimensional structure of the prefusion spike glycoprotein of the new betacoronavirus that could lead to the development of a vaccine to 2019-nCoV. In order to do that, we first calculated the B-cell epitopes that are predicted using fourteen different mathematical algorithms. Later, we obtained the consensus of B-cell epitopes according to the Similarity Index, and finally selecting the best candidates according to the results of a function called <F> which is evaluated for the glycoprotein. The best candidates that we obtained in order to design a vaccine are SSANNCT, PLQSYGFQPT, TESNKKFLP, NNSYEC, AENS, LPDPSK and YDPLQPE.
Keywords: Coronavirus; 2019-nCoV; Covid-19; Epitope; B cell; vaccine